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[根除幽门螺杆菌在胃溃疡愈合及复发中的作用]

[The role of eradication of Helicobacter pylori in healing and recurrence of gastric ulcer].

作者信息

Fukuda Y, Yamamoto I, Tonokatsu Y, Shimoyama T

机构信息

Department of Internal Medicine 4, Hyogo College of Medicine.

出版信息

Nihon Rinsho. 1993 Dec;51(12):3278-84.

PMID:7904321
Abstract

It is now generally accepted that infection with Helicobacter pylori is the most common cause of active chronic gastritis and duodenal ulceration. Although H. pylori is detected in the majority of patients with gastric ulcer, its pathogenicity and role in gastric ulceration remains unclear. One method to study this relationship is to eradicate H. pylori and observe the recurrence of gastric ulcer. In the present paper we examined the consequence of H. pylori eradication by antibiotics mono therapy with histamine H2 receptor antagonist on the recurrence of gastric ulcer. Two cases treated with proton pump inhibitor plus clarithromycin were reported. It is concluded that eradication of H. pylori infection may diminish the recurrence of gastric ulcers.

摘要

现在人们普遍认为,幽门螺杆菌感染是活动性慢性胃炎和十二指肠溃疡最常见的病因。虽然在大多数胃溃疡患者中都检测到了幽门螺杆菌,但其致病性以及在胃溃疡形成中的作用仍不清楚。研究这种关系的一种方法是根除幽门螺杆菌并观察胃溃疡的复发情况。在本文中,我们研究了使用组胺H2受体拮抗剂单一抗生素疗法根除幽门螺杆菌对胃溃疡复发的影响。报告了2例用质子泵抑制剂加克拉霉素治疗的病例。得出的结论是,根除幽门螺杆菌感染可能会减少胃溃疡的复发。

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