Lahti A, Haapaniemi T
Department of Dermatology, University of Oulu, Finland.
Acta Derm Venereol. 1993 Oct;73(5):350-1. doi: 10.2340/0001555573350351.
The initiation of the antihistamine effect of a single dose of acrivastine (8 mg) or cetirizine (10 mg) on wheals and itch induced by histamine dihydrochloride (10 mg/ml) in the prick test was studied in a randomized cross-over design employing 20 healthy medical students. The prick test was performed before ingestion of the drug and after 15, 20, 25, 30, 60 and 90 min and 2, 3 and 4 h. Local symptoms (itching) were recorded on a visual analogue scale. The inhibitory effect of acrivastine on the histamine wheal was first noticed 20 min (p < 0.01) after ingestion of the drug and that of cetirizine after 60 min (p < 0.001). The maximum effect of cetirizine, at 4 h, was greater than that of acrivastine, at 3 h (p < 0.001). The suppression of itching was first noticed 25 min after ingestion with both drugs.
采用随机交叉设计，对20名健康医学生研究了单剂量阿伐斯汀（8毫克）或西替利嗪（10毫克）对盐酸组胺（10毫克/毫升）皮内试验所致风团和瘙痒的抗组胺作用起始情况。在服药前以及服药后15、20、25、30、60和90分钟以及2、3和4小时进行皮内试验。局部症状（瘙痒）采用视觉模拟评分法记录。阿伐斯汀对组胺风团的抑制作用在服药后20分钟首次显现（p<0.01），西替利嗪则在60分钟后显现（p<0.001）。西替利嗪在4小时时的最大作用大于阿伐斯汀在3小时时的最大作用（p<0.001）。两种药物在服药后25分钟均首次出现瘙痒抑制情况。
