Coodley G O, Coodley M K, Nelson H D, Loveless M O
Oregon Health Sciences University, Portland 97201-3098.
AIDS. 1993 Dec;7(12):1595-600. doi: 10.1097/00002030-199312000-00008.
We measured micronutrient values in patients with the HIV wasting syndrome and in other HIV-seropositive patients to determine whether specific micronutrient deficiencies were associated with the wasting syndrome.
Serum from 47 HIV-seropositive patients was evaluated for concentrations of vitamin A, B6, B12, C, D, E, folate, the mineral zinc, carotene and glutathione. Comparisons were made between groups stratified by CD4 cell count and wasting/non-wasting status.
Mean serum levels were significantly lower for vitamin A (P = 0.04), folate (P = 0.04) and carotene (P = 0.06) in patients with the HIV wasting syndrome than in non-wasting patients with comparable CD4 cell counts. Values of vitamins A, B6, C, D, carotene and glutathione were below the normal range in over 10% of HIV-seropositive patients in this study.
Decreased micronutrient concentrations are common in HIV-infected patients and occur more frequently in patients with the wasting syndrome. Clinicians may wish to evaluate HIV-seropositive patients with wasting for individual micronutrient deficiencies, although they should note that particular deficiencies may be only part of the larger picture of malabsorption and undernutrition.
我们测量了患有HIV消瘦综合征的患者以及其他HIV血清阳性患者的微量营养素值，以确定特定的微量营养素缺乏是否与消瘦综合征相关。
对47例HIV血清阳性患者的血清进行维生素A、B6、B12、C、D、E、叶酸、矿物质锌、胡萝卜素和谷胱甘肽浓度的评估。对按CD4细胞计数和消瘦/非消瘦状态分层的组进行比较。
与具有可比CD4细胞计数的非消瘦患者相比，患有HIV消瘦综合征的患者血清维生素A（P = 0.04）、叶酸（P = 0.04）和胡萝卜素（P = 0.06）的平均水平显著较低。在本研究中，超过10%的HIV血清阳性患者的维生素A、B6、C、D、胡萝卜素和谷胱甘肽值低于正常范围。
微量营养素浓度降低在HIV感染患者中很常见，在消瘦综合征患者中更频繁发生。临床医生可能希望评估患有消瘦的HIV血清阳性患者是否存在个体微量营养素缺乏，尽管他们应该注意到特定的缺乏可能只是吸收不良和营养不良这一更大问题的一部分。
