Hsu W H, Chiang C D, Huang P L
Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, R.O.C.
J Formos Med Assoc. 1993 Jul;92(7):668-70.
To investigate the diagnostic value of adenosine deaminase (ADA) in immunocompromised hosts with tuberculous pleural effusions, we collected and checked 60 pleural effusion specimens from admitted patients. These patients were divided into three groups: group I (n = 20), immunocompetent hosts with tuberculous pleural effusions; group II (n = 10), immunocompromised hosts with tuberculous pleural effusions; and group III (n = 30), patients with malignant pleural effusions. Using statistical analysis to compare the ADA value in each group, the p value was found to be significant between groups I and II (p < 0.01), groups I and III (p < 0.001) and groups I+II and III (p < 0.001); however, the p value was not significant between groups II and III. If the lowest ADA value for the tuberculous pleural effusion was designed as 80 U/L, the sensitivity/specificity was 1.0/0.90 (group I), 0.40/0.90 (group II), and 0.80/0.90 (group I+II), respectively. We conclude that the diagnostic value of ADA in immunocompromised hosts with tuberculous pleural effusions is not as significant as in immunocompetent hosts.
为研究腺苷脱氨酶（ADA）在免疫功能低下合并结核性胸腔积液患者中的诊断价值，我们收集并检查了60例入院患者的胸腔积液标本。这些患者被分为三组：第一组（n = 20），免疫功能正常的结核性胸腔积液患者；第二组（n = 10），免疫功能低下的结核性胸腔积液患者；第三组（n = 30），恶性胸腔积液患者。通过统计分析比较每组的ADA值，发现第一组和第二组之间（p < 0.01）、第一组和第三组之间（p < 0.001）以及第一组 + 第二组和第三组之间（p < 0.001）的p值具有统计学意义；然而，第二组和第三组之间的p值无统计学意义。如果将结核性胸腔积液的最低ADA值设定为80 U/L，则敏感性/特异性分别为1.0/0.90（第一组）、0.40/0.90（第二组）和0.80/0.90（第一组 + 第二组）。我们得出结论，ADA在免疫功能低下合并结核性胸腔积液患者中的诊断价值不如在免疫功能正常患者中显著。
