Ramalingam V, Krishnamoorthy G, Govindarajulu P
Department of Endocrinology, Postgraduate Institute of Basic Medical Sciences, Taramani, Madras, India.
Neoplasma. 1993;40(6):363-7.
Alkaline phosphatase, 5'nucleotidase and gammaglutamyl transferase were studied in premenopausal and post-menopausal women with fibroadenoma and breast carcinoma tissues. The relationship of circulating estradiol (E2) and prolactin (Prl) with these enzymes was also investigated. All the three enzyme activities were found to be elevated in the breast carcinoma tissues of both pre- and postmenopausal groups. None of the membrane bound enzymes studied was altered in fibroadenoma breast tissues. The activities of all the three enzymes in breast carcinoma tissues were stimulated by the elevated level of serum Prl and further stimulated by a simultaneous increase in E2.
对患有纤维腺瘤和乳腺癌组织的绝经前和绝经后女性的碱性磷酸酶、5'-核苷酸酶和γ-谷氨酰转移酶进行了研究。还研究了循环雌二醇（E2）和催乳素（Prl）与这些酶的关系。发现绝经前和绝经后组的乳腺癌组织中所有这三种酶的活性均升高。在所研究的纤维腺瘤乳腺组织中，没有一种膜结合酶发生改变。乳腺癌组织中所有这三种酶的活性受到血清Prl水平升高的刺激，并在E2同时增加时进一步受到刺激。
