[Risk factors and correlations with some tumor markers in the incidence of breast cancer in pre- and post-menopausal patients].

Between January and November 1992, forty eight women with benign disorders of the breast were studied and compared with one hundred fifty two patients with malignant disease of the breast. The content of alkaline phosphatase (ALP) levels was measured in the serum of premenopausal and postmenopausal patients. In all of them clinical history was taken, weight size and corporal mass index (CMI) (weight/size2). When the patients were grouped according to type of breast lesions, it appeared that plasmatic ALP levels, were higher in the groups with infiltrating carcinoma than in the women with benign disorders of the breast. The physiological status of the enzyme in this study, relate probably the activity of the tissue in either benign or malignant tissue, through fibroadenoma had less activity than adenocarcinoma. Status ALP (> or = 90 UI/L), CMI, menstrual state and histological type were compared. We found a significant correlation between these parameters.