Insights into the role of the immune system in prion diseases.
作者信息
Berg L J
机构信息
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.
出版信息
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):429-32. doi: 10.1073/pnas.91.2.429.
Abstract
摘要
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Insights into the role of the immune system in prion diseases.对免疫系统在朊病毒疾病中作用的见解。
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):429-32. doi: 10.1073/pnas.91.2.429.
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本文引用的文献
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Mice devoid of PrP are resistant to scrapie.缺乏朊蛋白的小鼠对羊瘙痒病具有抵抗力。
Cell. 1993 Jul 2;73(7):1339-47. doi: 10.1016/0092-8674(93)90360-3.
2
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.在表达嵌合型朊蛋白基因的转基因小鼠中具有人工特性的朊病毒的传播。
Cell. 1993 Jun 4;73(5):979-88. doi: 10.1016/0092-8674(93)90275-u.
3
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.在小鼠中敲除朊病毒蛋白（PrP）基因可预防羊瘙痒病，并有助于抗PrP抗体的产生。
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10608-12. doi: 10.1073/pnas.90.22.10608.
4
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.表达髓鞘碱性蛋白特异性T细胞受体的转基因小鼠会自发产生自身免疫。
Cell. 1993 Feb 26;72(4):551-60. doi: 10.1016/0092-8674(93)90074-z.
5
Novel proteinaceous infectious particles cause scrapie.新型蛋白质感染性颗粒可引发羊瘙痒病。
Science. 1982 Apr 9;216(4542):136-44. doi: 10.1126/science.6801762.
6
Purification and structural studies of a major scrapie prion protein.一种主要瘙痒病朊病毒蛋白的纯化及结构研究
Cell. 1984 Aug;38(1):127-34. doi: 10.1016/0092-8674(84)90533-6.
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Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes.小鼠的克雅氏病：持续性病毒血症及病毒在低密度淋巴细胞中的优先复制
Infect Immun. 1983 Jul;41(1):154-61. doi: 10.1128/iai.41.1.154-161.1983.
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Pathogenesis of scrapie in the mouse: the role of the spleen.小鼠瘙痒病的发病机制：脾脏的作用。
Nature. 1970 May 2;226(5244):462-3. doi: 10.1038/226462a0.
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Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.
Nature. 1985;315(6017):331-3. doi: 10.1038/315331a0.
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A cellular gene encodes scrapie PrP 27-30 protein.
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