小鼠的克雅氏病：持续性病毒血症及病毒在低密度淋巴细胞中的优先复制
Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes.
作者信息
Kuroda Y, Gibbs C J, Amyx H L, Gajdusek D C
出版信息
Infect Immun. 1983 Jul;41(1):154-61. doi: 10.1128/iai.41.1.154-161.1983.
Abstract
The mode of replication of the "unconventional virus" of Creutzfeldt-Jakob disease was studied in BALB/c mice infected intracerebrally. Virus was detected in the brain, spleen, lung, thymus, liver, kidney, and blood, but not in urine, at various time intervals after inoculation. The highest infectivity was present in the spleen from the second through the ninth weeks postinfection. Density gradient separation of spleen cells with colloidal silica (Percoll) revealed that the highest concentration of virus was present in blastoid cells from lower-density (1.05 to 1.07 g/ml) fractions. These results suggest that blastoid cells play an important role as the initial replication site of virus in the pathogenesis of Creutzfeldt-Jakob disease in mice.
摘要
在经脑内接种感染的BALB/c小鼠中研究了克雅氏病“非常规病毒”的复制模式。接种后不同时间间隔，在脑、脾、肺、胸腺、肝、肾和血液中检测到病毒，但在尿液中未检测到。感染后第二周至第九周，脾脏中的传染性最高。用胶体二氧化硅（Percoll）对脾细胞进行密度梯度分离显示，病毒的最高浓度存在于低密度（1.05至1.07 g/ml）组分的胚样细胞中。这些结果表明，在小鼠克雅氏病的发病机制中，胚样细胞作为病毒的初始复制位点发挥着重要作用。
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