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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nasu T, Yamaguchi K, Shibata H

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Oct;106(2):377-81. doi: 10.1016/0742-8413(93)90149-f.

Preincubation with 1 or 2 mM Ni2+ inhibited dose-dependently the ileal phasic response to K+ (60 mM) without appreciable effects on the tonic response. Ni2+ above 3 mM inhibited the tonic response. 2. Ni2+ inhibited the high affinity Ca2+ sites than the low affinity sites during K+ contraction. 3. After treatment with Ni2+, the K+ response was fairly restored by a wash with normal medium. The nickel bound to the ileal cells was almost eliminated with the washing. 4. This probably indicates that Ni2+ mainly inhibited the K(+)-induced phasic tension by reducing Ca2+ release rather than Ca2+ influx.

用1或2 mM Ni2+预孵育剂量依赖性地抑制了回肠对K+（60 mM）的阶段性反应，而对紧张性反应无明显影响。3 mM以上的Ni2+抑制紧张性反应。2. 在K+收缩过程中，Ni2+对高亲和力Ca2+位点的抑制作用比对低亲和力位点的抑制作用更强。3. 用Ni2+处理后，通过用正常培养基冲洗，K+反应得到相当程度的恢复。冲洗几乎消除了与回肠细胞结合的镍。4. 这可能表明Ni2+主要通过减少Ca2+释放而不是Ca2+内流来抑制K+诱导的阶段性张力。

Nasu T, Yamaguchi K, Shibata H

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Oct;106(2):377-81. doi: 10.1016/0742-8413(93)90149-f.

Preincubation with 1 or 2 mM Ni2+ inhibited dose-dependently the ileal phasic response to K+ (60 mM) without appreciable effects on the tonic response. Ni2+ above 3 mM inhibited the tonic response. 2. Ni2+ inhibited the high affinity Ca2+ sites than the low affinity sites during K+ contraction. 3. After treatment with Ni2+, the K+ response was fairly restored by a wash with normal medium. The nickel bound to the ileal cells was almost eliminated with the washing. 4. This probably indicates that Ni2+ mainly inhibited the K(+)-induced phasic tension by reducing Ca2+ release rather than Ca2+ influx.

用1或2 mM Ni2+预孵育剂量依赖性地抑制了回肠对K+（60 mM）的阶段性反应，而对紧张性反应无明显影响。3 mM以上的Ni2+抑制紧张性反应。2. 在K+收缩过程中，Ni2+对高亲和力Ca2+位点的抑制作用比对低亲和力位点的抑制作用更强。3. 用Ni2+处理后，通过用正常培养基冲洗，K+反应得到相当程度的恢复。冲洗几乎消除了与回肠细胞结合的镍。4. 这可能表明Ni2+主要通过减少Ca2+释放而不是Ca2+内流来抑制K+诱导的阶段性张力。