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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nasu T, Ooyama I, Shibata H

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):97-102. doi: 10.1016/0742-8413(93)90118-5.

The high-K (60 mM)-induced ileal tonic tensions were not affected after 5 min with (0.01-1 mM) Cr6+. However, they were inhibited dose-dependently by Cr6+ after 30 min application. 2. Cr6+ inhibited the tonic response to K more strongly than the phasic response. 3. Cr6+ did not displace Ca(2+)-concentration-response curves to the right, although it reduced the Ca2+ response size. 4. The low affinity binding sites of Ca2+ and the tissue ATP concentration during K contraction was not entirely inhibited after 5 min with 0.5 mM Cr6+. However, they were fairly inhibited after 30 min with the Cr6+. 5. We suggest that Cr6+ probably reduced tension by the interference of Ca2+ influx at the cell membrane resulting from the inhibitory action on mitochondria.

高钾（60 mM）诱导的回肠紧张性张力在加入（0.01 - 1 mM）六价铬5分钟后未受影响。然而，在应用30分钟后，六价铬使其呈剂量依赖性抑制。2. 六价铬对钾的紧张性反应的抑制作用强于相性反应。3. 六价铬虽降低了钙离子反应幅度，但未使钙离子浓度 - 反应曲线右移。4. 用0.5 mM六价铬处理5分钟后，钾收缩期间钙离子的低亲和力结合位点及组织ATP浓度未被完全抑制。然而，在应用六价铬30分钟后，它们受到了相当程度的抑制。5. 我们认为，六价铬可能通过干扰线粒体外膜对钙离子内流的抑制作用来降低张力。

Nasu T, Ooyama I, Shibata H

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):97-102. doi: 10.1016/0742-8413(93)90118-5.

The high-K (60 mM)-induced ileal tonic tensions were not affected after 5 min with (0.01-1 mM) Cr6+. However, they were inhibited dose-dependently by Cr6+ after 30 min application. 2. Cr6+ inhibited the tonic response to K more strongly than the phasic response. 3. Cr6+ did not displace Ca(2+)-concentration-response curves to the right, although it reduced the Ca2+ response size. 4. The low affinity binding sites of Ca2+ and the tissue ATP concentration during K contraction was not entirely inhibited after 5 min with 0.5 mM Cr6+. However, they were fairly inhibited after 30 min with the Cr6+. 5. We suggest that Cr6+ probably reduced tension by the interference of Ca2+ influx at the cell membrane resulting from the inhibitory action on mitochondria.

高钾（60 mM）诱导的回肠紧张性张力在加入（0.01 - 1 mM）六价铬5分钟后未受影响。然而，在应用30分钟后，六价铬使其呈剂量依赖性抑制。2. 六价铬对钾的紧张性反应的抑制作用强于相性反应。3. 六价铬虽降低了钙离子反应幅度，但未使钙离子浓度 - 反应曲线右移。4. 用0.5 mM六价铬处理5分钟后，钾收缩期间钙离子的低亲和力结合位点及组织ATP浓度未被完全抑制。然而，在应用六价铬30分钟后，它们受到了相当程度的抑制。5. 我们认为，六价铬可能通过干扰线粒体外膜对钙离子内流的抑制作用来降低张力。