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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nasu T, Suzuki J, Shibata H

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):91-5. doi: 10.1016/0742-8413(93)90117-4.

In ileal longitudinal smooth muscle of the guinea-pig, lead ions (Pb2+) inhibited the phasic response to high-K+ (60 mM) solution more strongly than the tonic response. 2. Pb2+ displaced Ca2+ concentration-response curves to the right. Moreover, Pb2+ inhibited the 45Ca binding at high affinity sites determined by the La3+ method than low affinity sites during K(+)-induced contraction. 3. After treatment with Pb2+, the tonic tension caused by high-K+ was fairly restored by a wash with normal medium. The lead bound to the muscle cells was almost eliminated after 20-30 min with a normal medium. 4. We suggest that Pb2+ binds loosely to the surface membrane of ileal longitudinal muscle. Pb2+ probably reduced the tension in response to the high-K+ mainly by inhibiting Ca2+ release rather than by affecting Ca2+ influx.

在豚鼠回肠纵行平滑肌中，铅离子（Pb2+）对高钾（60 mM）溶液的相性反应的抑制作用比对紧张性反应的抑制作用更强。2. Pb2+使钙浓度-反应曲线右移。此外，在钾离子诱导的收缩过程中，用镧系元素（La3+）法测定，Pb2+对高亲和力位点的45Ca结合的抑制作用比对低亲和力位点的抑制作用更强。3. 用Pb2+处理后，用正常培养基冲洗可使高钾引起的紧张性张力相当程度地恢复。用正常培养基处理20 - 30分钟后，与肌肉细胞结合的铅几乎被消除。4. 我们认为Pb2+与回肠纵行肌的表面膜松散结合。Pb2+可能主要通过抑制钙释放而非影响钙内流来降低对高钾的张力反应。

Nasu T, Suzuki J, Shibata H

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):91-5. doi: 10.1016/0742-8413(93)90117-4.

In ileal longitudinal smooth muscle of the guinea-pig, lead ions (Pb2+) inhibited the phasic response to high-K+ (60 mM) solution more strongly than the tonic response. 2. Pb2+ displaced Ca2+ concentration-response curves to the right. Moreover, Pb2+ inhibited the 45Ca binding at high affinity sites determined by the La3+ method than low affinity sites during K(+)-induced contraction. 3. After treatment with Pb2+, the tonic tension caused by high-K+ was fairly restored by a wash with normal medium. The lead bound to the muscle cells was almost eliminated after 20-30 min with a normal medium. 4. We suggest that Pb2+ binds loosely to the surface membrane of ileal longitudinal muscle. Pb2+ probably reduced the tension in response to the high-K+ mainly by inhibiting Ca2+ release rather than by affecting Ca2+ influx.

在豚鼠回肠纵行平滑肌中，铅离子（Pb2+）对高钾（60 mM）溶液的相性反应的抑制作用比对紧张性反应的抑制作用更强。2. Pb2+使钙浓度-反应曲线右移。此外，在钾离子诱导的收缩过程中，用镧系元素（La3+）法测定，Pb2+对高亲和力位点的45Ca结合的抑制作用比对低亲和力位点的抑制作用更强。3. 用Pb2+处理后，用正常培养基冲洗可使高钾引起的紧张性张力相当程度地恢复。用正常培养基处理20 - 30分钟后，与肌肉细胞结合的铅几乎被消除。4. 我们认为Pb2+与回肠纵行肌的表面膜松散结合。Pb2+可能主要通过抑制钙释放而非影响钙内流来降低对高钾的张力反应。