Kimbrough T D, Weekley L B
Department of Biomedical Sciences, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg.
Toxicol Lett. 1994 Feb 1;70(2):165-70. doi: 10.1016/0378-4274(94)90160-0.
The ex vivo biophysical response of isolated rat aorta to T-2 toxin, diacetoxyscirpenol (DAS) and Roridin-A were determined. Roridin-A caused a dose-dependent relaxation of precontracted (30 mM KCl) aorta, while T-2 toxin and DAS were without effect. On the other hand, the relaxation response of aorta to isoproterenol and sodium fluoride is impaired in the presence of T-2 toxin or DAS. Roridin-A did not alter the relaxation response to isoproterenol or sodium fluoride. These experiments suggest that macrocyclic trichothecenes (e.g., Roridin-A) are capable of altering vascular smooth muscle tone directly, while simple trichothecenes (e.g., T-2 toxin, DAS) interfere with beta-adrenergic responses.
测定了离体大鼠主动脉对T-2毒素、二醋酸藨草镰刀菌烯醇（DAS）和Roridin-A的体外生物物理反应。Roridin-A可引起预收缩（30 mM氯化钾）主动脉呈剂量依赖性舒张，而T-2毒素和DAS则无此作用。另一方面，在存在T-2毒素或DAS的情况下，主动脉对异丙肾上腺素和氟化钠的舒张反应受损。Roridin-A不会改变对异丙肾上腺素或氟化钠的舒张反应。这些实验表明，大环单端孢霉烯族毒素（如Roridin-A）能够直接改变血管平滑肌张力，而简单的单端孢霉烯族毒素（如T-2毒素、DAS）会干扰β-肾上腺素能反应。
