Temocin S, Erenmemisoglu A, Suer C, Beydagi H
Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Jpn J Physiol. 1993;43(4):567-70. doi: 10.2170/jjphysiol.43.567.
In this study, endurance time in swimming exercise was evaluated in rats. Subcutaneous (S.C.) injection of nicotine decreased the endurance time in swimming exercise significantly, in a dose-dependent manner compared to the control group. At the dose of 0.125 mg/kg nicotine, the endurance time in swimming exercise remained unchanged, while at the doses of 0.25 and 0.375 mg/kg, it decreased significantly (p < 0.05 and p < 0.01, respectively). This effect of nicotine was antagonized by pretreatment with hexamethonium 5 mg/kg S.C. These results suggest that nicotine may limit the physical performance.
在本研究中，对大鼠游泳运动的耐力时间进行了评估。与对照组相比，皮下注射尼古丁以剂量依赖的方式显著降低了游泳运动的耐力时间。在尼古丁剂量为0.125mg/kg时，游泳运动的耐力时间保持不变，而在剂量为0.25和0.375mg/kg时，耐力时间显著降低（分别为p<0.05和p<0.01）。尼古丁的这种作用可被5mg/kg皮下注射六甲铵预处理所拮抗。这些结果表明尼古丁可能会限制身体机能。
