降钙素基因相关肽对大鼠主动回避行为的影响。

Effects of CGRP on active avoidance behavior in rats.

作者信息

Kovács A, Telegdy G

机构信息

Department of Pathophysiology, A. Szent-Györgyi Medical University, Hungary.

出版信息

Physiol Behav. 1995 Sep;58(3):429-35. doi: 10.1016/0031-9384(95)00066-r.

DOI:10.1016/0031-9384(95)00066-r

PMID:8587948

Abstract

The effects of calcitonin gene-related peptide (CGRP) on the extinction of active avoidance behaviour was examined in rats. Three doses (250 ng, 500 ng and 1 microgram) of the peptide were administered into the lateral brain ventricle (i.c.v.). CGRP delayed the extinction of an active avoidance response in a dose-dependent manner. To reveal any role of the transmitter systems in the action of exogenously administered CGRP, the animals were pretreated with different receptor blockers. CGRP induced a delay in the extinction of an active avoidance response, which could be prevented by haloperidol, propranolol, methysergide and naloxone. Phenoxybenamine, atropine and bicuculline were ineffective. The data suggest that dopaminergic, beta adrenergic, serotonergic and opiate transmission are involved in the CGRP-induced behavioral alterations.

摘要

研究了降钙素基因相关肽（CGRP）对大鼠主动回避行为消退的影响。将该肽的三个剂量（250纳克、500纳克和1微克）注入侧脑室（脑室内）。CGRP以剂量依赖的方式延迟了主动回避反应的消退。为了揭示递质系统在外源性给予CGRP作用中的任何作用，对动物进行了不同受体阻滞剂的预处理。CGRP导致主动回避反应消退延迟，氟哌啶醇、普萘洛尔、麦角新碱和纳洛酮可阻止这种延迟。酚苄明、阿托品和荷包牡丹碱无效。数据表明，多巴胺能、β肾上腺素能、5-羟色胺能和阿片样物质传递参与了CGRP诱导的行为改变。