Prabhala R H, Braune L M, Garewal H S, Watson R R
Department of Microbiology, Chicago College of Osteopathic Medicine, Downers Grove, Illinois 60515.
Ann N Y Acad Sci. 1993 Dec 31;691:262-3. doi: 10.1111/j.1749-6632.1993.tb26189.x.
Recent reports have demonstrated that beta-carotene, a nontoxic carotenoid, is able to stimulate immune functions in humans. The purpose of this study is to understand the mechanisms of immunoenhancement by carotenoids in order to explain their anticancer effects. We have evaluated the clinical efficacy of beta-carotene, given 30 mg/day orally, for treatment of oral leukoplakia patients. Patients who responded to beta-carotene treatment showed increased plasma levels of TNF-alpha. Epithelial cells from these patients were characterized in vitro. These results may lead to a better understanding of the therapeutic use of beta-carotene in humans.
最近的报告表明，β-胡萝卜素，一种无毒的类胡萝卜素，能够刺激人体的免疫功能。本研究的目的是了解类胡萝卜素免疫增强的机制，以便解释它们的抗癌作用。我们评估了每天口服30毫克β-胡萝卜素治疗口腔白斑患者的临床疗效。对β-胡萝卜素治疗有反应的患者血浆肿瘤坏死因子-α水平升高。对这些患者的上皮细胞进行了体外特征分析。这些结果可能有助于更好地理解β-胡萝卜素在人体中的治疗用途。
