Ayer L M, Rubin R L, Dixon G H, Fritzler M J
Department of Medicine, University of Calgary, Alberta, Canada.
Arthritis Rheum. 1994 Jan;37(1):98-103. doi: 10.1002/art.1780370115.
To determine the prevalence of autoantibodies to high-mobility group (HMG) proteins in sera from patients with drug-induced lupus (DIL).
Forty-two patients who developed autoantibodies and/or lupus after treatment with procainamide or other drugs were tested for HMG autoantibodies by immunoblotting and enzyme-linked immunosorbent assay (ELISA).
Twenty-eight of the 42 sera (67%) bound HMG-14 and/or HMG-17. In comparison, 9 of 42 (21%) bound HMG-1 and/or HMG-2. There was a good correlation between ELISA results and binding on immunoblots.
The high prevalence of antibodies to the nucleosomal core HMGs (HMG-14 and HMG-17) in DIL patients adds evidence implicating nucleosomes as immunogens in drug-induced autoimmunity.
确定药物性狼疮（DIL）患者血清中高迁移率族（HMG）蛋白自身抗体的患病率。
对42例在用普鲁卡因胺或其他药物治疗后出现自身抗体和/或狼疮的患者，通过免疫印迹法和酶联免疫吸附测定（ELISA）检测HMG自身抗体。
42份血清中有28份（67%）与HMG - 14和/或HMG - 17结合。相比之下，42份中有9份（21%）与HMG - 1和/或HMG - 2结合。ELISA结果与免疫印迹上的结合情况有良好的相关性。
DIL患者中核小体核心HMGs（HMG - 14和HMG - 17）抗体的高患病率进一步证明核小体作为药物诱导自身免疫中的免疫原。
