Paro R
University of Heidelberg, Germany.
Curr Opin Cell Biol. 1993 Dec;5(6):999-1005. doi: 10.1016/0955-0674(93)90084-4.
During development, patterns of differential gene expression, defining determined states of cells, need to be maintained over many cell generations. In Drosophila, genetic and molecular analyses led to the discovery of a set of proteins which seem to exert such a memory function by using epigenetic mechanisms. Recent experiments demonstrate that, in particular, the heritable inactivation of regulatory genes relies on stable changes in the higher-order constitution of chromatin.
在发育过程中，定义细胞特定状态的差异基因表达模式需要在许多细胞世代中得以维持。在果蝇中，遗传和分子分析促使人们发现了一组蛋白质，它们似乎通过表观遗传机制发挥这种记忆功能。最近的实验表明，特别是调控基因的可遗传失活依赖于染色质高阶结构的稳定变化。
