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Imprinting a determined state into the chromatin of Drosophila.

作者信息

Paro R

机构信息

Zentrum für Molekulare Biologie, Universität Heidelberg, FRG.

出版信息

Trends Genet. 1990 Dec;6(12):416-21. doi: 10.1016/0168-9525(90)90303-n.

DOI:10.1016/0168-9525(90)90303-n
PMID:1982376
Abstract

The Polycomb gene of Drosophila melanogaster is a member of a class of genes involved in the clonal transmission of the repressed state of bomeotic regulatory genes through development. Genetic evidence, and the finding of a molecular similarity between the Polycomb protein and a heterochromatin-associated protein of Drosophila, suggest that this mechanism of repression might be imprinted in the structure of the chromatin, rather than being sustained through the action of diffusible regulatory factors.

摘要

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