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CBA/H小鼠中白色念珠菌抗原抗体的产生。

Production of antibodies to antigens of Candida albicans in CBA/H mice.

作者信息

Costantino P J, Franklyn K M, Gare N F, Warmington J R

机构信息

School of Biomedical Sciences, Curtin University of Technology, Bentley, Perth, Australia.

出版信息

Infect Immun. 1994 Apr;62(4):1400-5. doi: 10.1128/iai.62.4.1400-1405.1994.

DOI:10.1128/iai.62.4.1400-1405.1994
PMID:7907579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186293/
Abstract

Reported targets of the specific immune responses to Candida albicans in human candidiasis include a 47-kDa breakdown product of a 90-kDa heat shock protein (HSP 90) (R. Matthews and J. Burnie, FEMS Microbiol. Lett. 60:25-30, 1989) and the 48-kDa enolase (K.M. Franklyn, J.R. Warmington, A.K. Ott, and R.B. Ashman, Immunol. Cell Biol. 68:173-178, 1990). These proteins are immunodominant antigens of C. albicans. Western blotting (immunoblotting) and immunoprecipitation were used to investigate the humoral response in a mouse model of systemic candidiasis. Resolution of systemic candidiasis in CBA/H mice is associated with a high level of antibody reactivity to C. albicans antigens. A significant antibody response against a non-HSP antigen of 96 kDa which was distinct from the C. albicans HSP 90 antigen was detected. Significant antibody reactivity against an HSP of 75 kDa was also detected. We concluded that resolution of C. albicans infections in CBA/H mice was associated with antibodies to an HSP and a non-HSP of 75 and 96 kDa, respectively.

摘要

据报道，人类念珠菌病中针对白色念珠菌的特异性免疫反应的靶标包括一种90 kDa热休克蛋白（HSP 90）的47 kDa降解产物（R. 马修斯和J. 伯尼，《FEMS微生物学快报》60:25 - 30，1989年）以及48 kDa烯醇酶（K.M. 富兰克林、J.R. 沃明顿、A.K. 奥特和R.B. 阿什曼，《免疫与细胞生物学》68:173 - 178，1990年）。这些蛋白质是白色念珠菌的免疫显性抗原。采用蛋白质印迹法（免疫印迹法）和免疫沉淀法研究系统性念珠菌病小鼠模型中的体液反应。CBA/H小鼠系统性念珠菌病的消退与对白念珠菌抗原的高水平抗体反应性相关。检测到针对一种96 kDa非HSP抗原的显著抗体反应，该抗原与白色念珠菌HSP 90抗原不同。还检测到针对一种75 kDa HSP的显著抗体反应性。我们得出结论，CBA/H小鼠白色念珠菌感染的消退分别与针对75 kDa HSP和96 kDa非HSP的抗体有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/772e75026aef/iai00004-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/83f2f30b7d48/iai00004-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/4cfe1b87815b/iai00004-0282-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/f4266a4cb59a/iai00004-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/e203f00e589e/iai00004-0283-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/772e75026aef/iai00004-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/83f2f30b7d48/iai00004-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/4cfe1b87815b/iai00004-0282-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/f4266a4cb59a/iai00004-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/e203f00e589e/iai00004-0283-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b80/186293/772e75026aef/iai00004-0284-a.jpg

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