Matthews R, Burnie J, Smith D, Clark I, Midgley J, Conolly M, Gazzard B
Department of Medical Microbiology, St Bartholomew's Hospital, London.
Lancet. 1988 Jul 30;2(8605):263-6. doi: 10.1016/s0140-6736(88)92547-0.
Clinical observation and animal models of candidosis suggest that, although T lymphocytes are important in preventing superficial candidosis, defence against systemic candidosis depends upon humoral immunity. An antibody response to the immunodominant 47 kD antigen of Candida albicans is invariably associated with recovery. The presence of this antibody in patients with chronic mucocutaneous candidosis and the acquired immunodeficiency syndrome (AIDS) could account for the rarity of disseminated candidal infection in these conditions. Polyclonal B cell activation may be responsible for the frequency with which this antibody is produced in AIDS. Antibody to the 47 kD antigen could be useful in the treatment and prevention of systemic candidosis, though not in the superficial candidosis of AIDS.
念珠菌病的临床观察和动物模型表明，虽然T淋巴细胞在预防浅表念珠菌病中很重要，但抵御全身性念珠菌病则依赖于体液免疫。对白色念珠菌免疫显性47 kD抗原的抗体反应总是与康复相关。慢性黏膜皮肤念珠菌病和获得性免疫缺陷综合征（AIDS）患者体内存在这种抗体，这可以解释在这些情况下播散性念珠菌感染为何罕见。多克隆B细胞活化可能是AIDS患者中产生这种抗体频率较高的原因。针对47 kD抗原的抗体可能对全身性念珠菌病的治疗和预防有用，但对AIDS的浅表念珠菌病无效。
