Ashman R B, Papadimitriou J M
Clinical Immunology Research Unit, Princess Margaret Hospital for Children, Subiaco, WA.
Immunol Cell Biol. 1988 Jan;66 ( Pt 3):231-7. doi: 10.1038/icb.1988.29.
After recovery from acute infection with live Candida albicans, both CBA/H and BALB/c mice show increased resistance to colonization by the organism. However, the 'susceptible' CBA/H mice develop much stronger protective responses than do 'resistant' BALB/c mice. This is manifested particularly as a substantial amelioration of the severity of the lesions in the brain, and a very marked reduction in the number of fungal units therein. Analysis of granulocyte function in normal and immune mice of the two strains tended to exclude this as a basis for the different patterns of susceptibility and resistance.
在从白色念珠菌急性感染中恢复后，CBA/H和BALB/c小鼠对该病原体的定植均表现出抵抗力增强。然而，“易感”的CBA/H小鼠比“抗性”的BALB/c小鼠产生更强的保护性反应。这尤其表现为大脑中病变严重程度的显著改善，以及其中真菌单位数量的非常明显减少。对这两个品系的正常和免疫小鼠的粒细胞功能分析倾向于排除这作为易感性和抗性不同模式的基础。
