Buitelaar J K
Department of Child and Adolescent Psychiatry, University of Utrecht, The Netherlands.
Acta Paedopsychiatr. 1993;56(2):105-11.
Self-injurious behaviour (SIB) is a frequently occurring and serious problem in autistic and non-autistic retarded children. This paper first summarizes clinical knowledge on SIB. Attention is paid to the Lesch-Nyhan syndrome and Tourette's syndrome as examples of clinical syndromes that are particularly associated with SIB. Then animal models are reviewed that suggest the involvement of dopaminergic, opioidergic and serotonergic mechanisms in the pathophysiology of SIB. The putative biochemical models of SIB in humans are discussed and pharmacological interventions are briefly outlined.
自伤行为（SIB）在自闭症和非自闭症智障儿童中是一个经常出现且严重的问题。本文首先总结了关于自伤行为的临床知识。以莱施-奈恩综合征和图雷特综合征为例，关注那些与自伤行为特别相关的临床综合征。接着回顾了动物模型，这些模型表明多巴胺能、阿片样物质能和5-羟色胺能机制参与了自伤行为的病理生理学过程。讨论了人类自伤行为的假定生化模型，并简要概述了药物干预措施。
