Schroeder S R, Oster-Granite M L, Berkson G, Bodfish J W, Breese G R, Cataldo M F, Cook E H, Crnic L S, DeLeon I, Fisher W, Harris J C, Horner R H, Iwata B, Jinnah H A, King B H, Lauder J M, Lewis M H, Newell K, Nyhan W L, Rojahn J, Sackett G P, Sandman C, Symons F, Tessel R E, Thompson T, Wong D F
University of Kansas, Lawrence, Kansas 66045, USA.
Ment Retard Dev Disabil Res Rev. 2001;7(1):3-12. doi: 10.1002/1098-2779(200102)7:1<3::AID-MRDD1002>3.0.CO;2-#.
This paper summarizes a conference held at the National Institute of Child Health and Human Development on December 6-7, 1999, on self-injurious behavior [SIB] in developmental disabilities. Twenty-six of the top researchers in the U.S. from this field representing 13 different disciplines discussed environmental mechanisms, epidemiology, behavioral and pharmacological intervention strategies, neurochemical substrates, genetic syndromes in which SIB is a prominent behavioral phenotype, neurobiological and neurodevelopmental factors affecting SIB in humans as well as a variety of animal models of SIB. Findings over the last decade, especially new discoveries since 1995, were emphasized. SIB is a rapidly growing area of scientific interest to both basic and applied researchers. In many respects it is a model for the study of gene-brain-behavior relationships in developmental disabilities.
本文总结了1999年12月6日至7日在美国国家儿童健康与人类发展研究所召开的关于发育障碍中的自伤行为（SIB）的会议。来自该领域的26位美国顶尖研究人员，代表13个不同学科，讨论了环境机制、流行病学、行为和药物干预策略、神经化学底物、以SIB为突出行为表型的遗传综合征、影响人类SIB的神经生物学和神经发育因素以及SIB的各种动物模型。重点强调了过去十年的研究发现，尤其是1995年以来的新发现。SIB是基础研究人员和应用研究人员都迅速感兴趣的科学领域。在许多方面，它是研究发育障碍中基因-脑-行为关系的一个模型。
