乳腺外佩吉特病中c-erbB-2癌蛋白表达的免疫组织化学研究

Immunohistochemical study of c-erbB-2 oncoprotein expression in extramammary Paget's disease.

作者信息

Nishi M, Yoshida H, Setoyama M, Tashiro M

机构信息

Department of Dermatology, Faculty of Medicine, Kagoshima University, Japan.

出版信息

Dermatology. 1994;188(2):100-2. doi: 10.1159/000247110.

DOI:10.1159/000247110

PMID:7907892

Abstract

Sections of formalin-fixed, paraffin-embedded tumor tissue from 20 patients with noninvasive extramammary Paget's disease and 2 patients with invasive extramammary Paget's disease were stained immunohistochemically by means of anti-c-erbB-2 product monoclonal antibody. Membrane staining of intraepidermal tumor cells was found in only 3 of 20 cases of noninvasive extramammary Paget's disease. In the 2 invasive cases, tumor cells of invasive lesions and metastases were positive while intraepidermal tumor cells were negative.

摘要

对20例非侵袭性乳腺外佩吉特病患者及2例侵袭性乳腺外佩吉特病患者的福尔马林固定、石蜡包埋肿瘤组织切片，采用抗c-erbB-2产物单克隆抗体进行免疫组织化学染色。在20例非侵袭性乳腺外佩吉特病病例中，仅3例发现表皮内肿瘤细胞有膜染色。在2例侵袭性病例中，侵袭性病变及转移灶的肿瘤细胞呈阳性，而表皮内肿瘤细胞呈阴性。