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[γ-谷氨酰转移酶与血液酒精水平——汽车驾驶员酒精风险标准。对初犯酒精违法者医学心理学研究指南的批判性评论]

[Gamma-glutamyltransferase and blood alcohol level--criteria for alcohol risk in automobile drivers. A critical comment on the guidelines for medical-psychological studies of first-time alcohol offenders].

作者信息

Iffland R, Grellner W

机构信息

Institut für Rechtsmedizin, Universität zu Köln.

出版信息

Blutalkohol. 1994 Jan;31(1):8-23.

PMID:7908206
Abstract

GGT and blood alcohol concentration (BAC) were measured of 2,655 male car drivers using alcoholized their cars during the year 1991 in the area of the city of Cologne. The results were evaluated statistically together with other parameters like age, time of taking blood sample and behaviour while drunken. BAC was 1.6% and more in 30.5% of all cases. Half of them had levels of 2.0% and higher. GGT in serum was increased (> 28 U/l) at 29.5% of the drivers, in 6% even above 100 U/l. 53% were younger than 31 years. Medium BAC and part of GGT higher than 28 U/l were remarkable lower in this group than at the older ones. 50% of all car drivers with blood alcohol levels above 2.0% have alcohol problems regarding GGT. Problem drinkers were found among the younger ones to an extent of 15%, but of 50% among the drivers older than 40 years. But also 25% of all with a BAC lower than 1.6% showed increased GGT levels. They remain undetected on account of the present instructions of MPA though there is a great danger repeating drunken driving. On the other side nearly 50% of those driving with an BAC of 1.6% or more are no driving drinkers regarding GGT but have to undergo MPA. The recommendation of the 30. German Traffic Courts Meeting in 1992 to determine other indicators of alcohol habituation in the blood samples taken after drunken driving like GGT and methanol should be taken in a corrected setting of the instructions. This would regard fairer the problems of an individual case. The connection of MPA with the height of BAC and other circumstances seen as indicators for extraordinary alcohol habituation is a wrong way and unnecessary if alcoholism markers are used like GGT, CDT and methanol.

摘要

1991年,在科隆市对2655名在车内饮酒的男性汽车司机进行了γ-谷氨酰转移酶(GGT)和血液酒精浓度(BAC)检测。研究结果与年龄、采血时间和醉酒时的行为等其他参数一起进行了统计学评估。在所有案例中,30.5%的司机BAC达到或超过1.6%。其中一半人的BAC水平达到或超过2.0%。29.5%的司机血清GGT升高(>28 U/l),6%的司机GGT甚至高于100 U/l。53%的司机年龄小于31岁。该组的平均BAC以及GGT高于28 U/l的比例显著低于年龄较大的司机。所有BAC高于2.0%的汽车司机中,50%在GGT方面存在酒精问题。在较年轻的司机中,有问题饮酒者的比例为15%,但在40岁以上的司机中这一比例为50%。不过,在所有BAC低于1.6%的司机中,也有25%的人GGT水平升高。尽管存在再次酒驾的巨大风险,但根据药物和成瘾问题联邦研究所(MPA)目前的指导方针,这些人未被发现。另一方面,近50%的BAC为1.6%或更高的司机在GGT方面并非酒驾者,但却必须接受MPA检查。1992年德国第30届交通法庭会议建议,在酒驾后采集的血样中确定其他酒精成瘾指标,如GGT和甲醇,应在修正的指导方针中予以考虑。这样能更公平地处理个别案例。如果使用GGT、CDT和甲醇等酒精中毒标志物,将MPA与BAC水平以及其他被视为异常酒精成瘾指标的情况联系起来是错误的做法,也是不必要的。

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