通过抑制无毛小鼠皮肤中紫外线A诱导的中性粒细胞浸润快速测定局部用皮质类固醇的抗炎活性。II. 名牌产品与仿制药效的评估。
Rapid assay of the anti-inflammatory activity of topical corticosteroids by inhibition of a UVA-induced neutrophil infiltration in hairless mouse skin. II. Assessment of name brand versus generic potency.
作者信息
Kligman L H
机构信息
University of Pennsylvania School of Medicine, Department of Dermatology, Philadelphia.
出版信息
Acta Derm Venereol. 1994 Jan;74(1):18-9. doi: 10.2340/00015555741819.
PMID:7908480
Abstract
The hairless mouse model of a UVA-induced dermal neutrophilic infiltrate was used to compare the efficacy of equal concentrations of name brand versus generic corticosteroids. The generic brand was significantly less effective in suppressing the inflammatory response.
摘要
利用无毛小鼠的UVA诱导的真皮嗜中性粒细胞浸润模型，比较同等浓度的名牌皮质类固醇与普通皮质类固醇的疗效。普通品牌在抑制炎症反应方面明显效果较差。
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