Eichhorn M, Jungkunz W, Wörl J, Marsch W C
Anatomisches Institut, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Acta Derm Venereol. 1994 Jan;74(1):51-3. doi: 10.2340/00015555745153.
A strong correlation has been found between carbonic anhydrase (CA) activity and fenestrations in juxtaepithelial capillaries of several tissues, including psoriatic lesions of human skin. In the present study we demonstrate that the majority of the capillaries in cherry hemangiomas are fenestrated and histochemically react CA positively. Obviously the occurrence of CA in these capillaries corresponds to the fenestrations of venous capillaries, which are numerously revealed by electron microscopy. In normal undiseased skin no capillary staining for CA was observed. Therefore in a large proportion of the capillaries of cherry hemangiomas the correlation between fenestrations and CA activity also exists. We suggest that the histochemical demonstration of CA activity might serve as a sensitive and simple marker for fenestrated capillaries in skin tissue.
在包括人类皮肤银屑病病变在内的多种组织的上皮下毛细血管中，已发现碳酸酐酶（CA）活性与窗孔之间存在强相关性。在本研究中，我们证明樱桃状血管瘤中的大多数毛细血管有窗孔，并且组织化学染色显示CA呈阳性。显然，这些毛细血管中CA的存在与静脉毛细血管的窗孔相对应，电子显微镜大量显示了静脉毛细血管的窗孔。在正常无病变的皮肤中未观察到CA的毛细血管染色。因此，在樱桃状血管瘤的大部分毛细血管中，窗孔与CA活性之间也存在相关性。我们认为，CA活性的组织化学证明可能作为皮肤组织中有窗孔毛细血管的敏感而简单的标志物。
