Jungkunz W, Eichhorn M, Wörl J, Marsch W C, Holzmann H
Zentrum der Dermatologie und Venerologie, J. W. Goethe-Universität, Frankfurt am Main, Federal Republic of Germany.
Arch Dermatol Res. 1992;284(3):146-9. doi: 10.1007/BF00372707.
A strong correlation between capillary fenestrations and the demonstration of carbonic anhydrase (CA) has previously been shown. In the present histochemical study we sought to determine whether CA could serve as a marker for fenestrated capillaries in psoriasis. In normal human skin capillary staining for CA was found only in the fenestrated capillaries of the perifollicular and periglandular plexus. In psoriatic skin lesions, however, the intrapapillary capillaries also reacted for CA. From ultrastructural investigations it is known that these capillaries are fenestrated. Our findings have shown that there is a strong correlation between fenestrated and CA-positive capillaries in normal human skin as well as in the lesional skin of psoriatics. Therefore, the demonstration of CA activity may serve as a specific and sensitive marker for fenestrated capillaries in psoriasis using an uncomplicated method, which makes it possible to detect numerous fenestrated capillaries in a single histological section.
先前已表明毛细血管窗孔与碳酸酐酶（CA）的显示之间存在强烈关联。在本组织化学研究中，我们试图确定CA是否可作为银屑病中窗孔状毛细血管的标志物。在正常人类皮肤中，CA的毛细血管染色仅在毛囊周和腺周丛的窗孔状毛细血管中发现。然而，在银屑病皮肤病变中，乳头内毛细血管也对CA有反应。从超微结构研究可知，这些毛细血管是有窗孔的。我们的研究结果表明，在正常人类皮肤以及银屑病患者的病变皮肤中，有窗孔的毛细血管与CA阳性毛细血管之间存在强烈关联。因此，使用一种简单的方法，CA活性的显示可作为银屑病中窗孔状毛细血管的特异性和敏感标志物，这使得在单个组织学切片中检测大量有窗孔的毛细血管成为可能。
