Wong S S, Marks R
Department of Dermatology, University of Wales College of Medicine, Cardiff, U.K.
Acta Derm Venereol. 1994 Jan;74(1):57-60. doi: 10.2340/00015555745760.
Cutaneous vasculitis has been reported as a complication of pustular psoriasis but not of plaque type psoriasis. In the past 5 years we have observed 3 patients who in the course of their psoriasis developed cutaneous vasculitis. Two of these patients also had severe psoriatic arthropathy and were on etretinate during the onset of vasculitis. However, there was no deterioration or recurrence of vasculitis whilst the patients were maintained on the drug. The third patient with vasculitis had not received retinoids. No obvious causes of vasculitis were found in the 3 patients and the rash resolved spontaneously without any systemic complications though surgical amputation was necessary in one case. None of the cases required immunosuppressive therapy and the skin lesions mostly resolved spontaneously. The mechanisms that triggered off vasculitis in our patients are unknown but are likely to be immune-mediated.
皮肤血管炎已被报道为脓疱型银屑病的一种并发症，但斑块型银屑病未见此并发症报道。在过去5年中，我们观察到3例银屑病患者在病程中发生了皮肤血管炎。其中2例患者还患有严重的银屑病关节炎，在血管炎发作时正在服用维甲酸。然而，在患者持续服用该药物期间，血管炎未恶化或复发。第3例血管炎患者未接受过维甲酸治疗。在这3例患者中未发现血管炎的明显病因，皮疹均自发消退，无任何全身并发症，尽管其中1例患者需要手术截肢。所有病例均无需免疫抑制治疗，皮肤病变大多自发消退。我们患者中引发血管炎的机制尚不清楚，但可能是免疫介导的。
