Arbuck S G, Dorr A, Friedman M A
Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.
Hematol Oncol Clin North Am. 1994 Feb;8(1):121-40.
Paclitaxel (Taxol) is a diterpine plant compound that was isolated initially from the bark of the western yew tree, Taxus brevifolia, but can now be produced by semisynthesis from a renewable source. Paclitaxel is the first new agent in the past decade to have confirmed single agent activity in breast cancer in excess of 50%. A 28% response rate has been reported in doxorubicin-refractory patients. Ongoing studies include attempts to combine paclitaxel with other drugs used for breast cancer treatment and with radiation.
紫杉醇（泰素）是一种二萜类植物化合物，最初从太平洋紫杉树（短叶红豆杉）的树皮中分离出来，但现在可以通过可再生资源进行半合成生产。紫杉醇是过去十年中第一种被证实对乳腺癌单药活性超过50%的新药。在对阿霉素耐药的患者中报告的缓解率为28%。正在进行的研究包括尝试将紫杉醇与其他用于乳腺癌治疗的药物以及放疗联合使用。
