Hecht K, Hai N V, Moritz V, Hecht T
Acta Biol Med Ger. 1976;35(1):23-33.
The influence of light, medium, and heavy chronic stress upon cerebro-visceral functions following 3 and 5 weeks of daily stress exposure was examined. The following results were obtained: Light stress produced no changes of cerebro-visceral functions. Medium stress restricted the learning and memory capacity, increased systolic blood pressure, fasting blood sugar and adrenal weights. The B-cells of the pancreatic islets showed degranulations of varying intensity. Heavy stress diminished the learning and memory capacity, increased adrenal weights and led to hypergranulation of the pancreatic B-cells. Blood sugar and blood pressure values fall within physiological limits. Load tests, however, revealed in these animals symptoms of premorbid states. Since throughout the period of observation, light stress stablized the regulation processes, medium stress induced early stages of pathological processes, and heavy stress caused premorbid states, no linearity could be established between the load intensity and the changes of cerebro-visceral functions.
研究了轻度、中度和重度慢性应激在每日应激暴露3周和5周后对脑-内脏功能的影响。得到以下结果:轻度应激未引起脑-内脏功能变化。中度应激限制了学习和记忆能力,增加了收缩压、空腹血糖和肾上腺重量。胰岛B细胞出现不同程度的脱颗粒。重度应激降低了学习和记忆能力,增加了肾上腺重量,并导致胰岛B细胞颗粒增多。血糖和血压值在生理范围内。然而,负荷试验显示这些动物出现了疾病前期状态的症状。由于在整个观察期内,轻度应激稳定了调节过程,中度应激诱发了病理过程的早期阶段,重度应激导致了疾病前期状态,因此负荷强度与脑-内脏功能变化之间无法建立线性关系。