Hecht K, Hai N V, Hecht T, Moritz V, Woossmann H
Acta Biol Med Ger. 1976;35(1):35-45.
43 male albino rats were investigated to find out what are the effects of bilateral exclusion of pes hippocampus structures upon the development of arterial hypertension released by learning stress exposure. The following results were obtained: 5 weeks of stress exposure (learning load and heavy learning load) caused disturbances of information-processing events of the central nervous system in all the animals with hippocampal lesions. Systolic blood pressure values, fasting blood sugar values, and adrenal weights fall within the physiological range. The B-cells of the pancreatic islets show hypergranulation. Functional tests of the blood pressure under exercise load, and of blood sugar under glucose load revealed normal reactions in animals with hippocampal lesions. In animals with intact brains the same stress exposure caused pathologic malfunctioning (under learning stress) or even premorbid states. The results being considered in relation to the pathogenesis of arterial hypertension show that the exclusion of circumscribed areas of the hippocampus prevents the development of permanent, stress-induced emotional excitations spreading into the viscerum.
对43只雄性白化大鼠进行了研究,以确定双侧切除海马结构对学习应激暴露引发的动脉高血压发展有何影响。获得了以下结果:5周的应激暴露(学习负荷和重学习负荷)导致所有海马损伤动物的中枢神经系统信息处理事件紊乱。收缩压值、空腹血糖值和肾上腺重量均在生理范围内。胰岛的B细胞显示颗粒增多。运动负荷下的血压功能测试和葡萄糖负荷下的血糖功能测试显示,海马损伤动物的反应正常。在大脑完整的动物中,相同的应激暴露会导致病理功能障碍(在学习应激下)甚至病前状态。结合动脉高血压的发病机制考虑这些结果表明,切除海马的特定区域可防止永久性的、应激诱导的情绪兴奋扩散至内脏,从而预防动脉高血压的发展。