zur Hausen H
Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Lancet. 1994 Apr 16;343(8903):955-7. doi: 10.1016/s0140-6736(94)90070-1.
The role of specific human papillomaviruses (HPVs) in the aetiology of cancer of the cervix is firmly established. Progression of an HPV-infected cell clone to invasive growth involves consecutive modifications of a set of host cell genes. Some of these modifications suppress viral oncogene functions post-transcriptionally, and others suppress transcription via a signalling pathway stimulated by activated macrophages and possibly by additional cells. I describe a scheme that tries to unify available data by postulating the existence of two intracellular signalling pathways in the control of latent HPV infections.
特定人类乳头瘤病毒（HPV）在子宫颈癌病因学中的作用已得到确证。HPV感染的细胞克隆向侵袭性生长的进展涉及一系列宿主细胞基因的连续修饰。其中一些修饰在转录后抑制病毒癌基因功能，另一些则通过由活化巨噬细胞以及可能由其他细胞刺激的信号通路抑制转录。我描述了一个方案，该方案试图通过假定在潜伏性HPV感染控制中存在两条细胞内信号通路来统一现有数据。
