Grace D, Milligan K R, Loughran P G, McCaughey W
Department of Anaesthetics, Craigavon Area Hospital, N. Ireland.
Acta Anaesthesiol Scand. 1994 May;38(4):342-5. doi: 10.1111/j.1399-6576.1994.tb03904.x.
The effectiveness of an anaesthetic technique employing diclofenac sodium as an analgesic given preoperatively by intramuscular injection was compared against one employing intravenous fentanyl in patients undergoing laparoscopic sterilization. Postoperative pain was marked and both drugs provided partial relief only. Patients in the diclofenac group had pain scores that were initially higher than those in the fentanyl group and the difference between the groups was statistically significant (P < 0.02). Patients in the diclofenac group who received postoperative supplemental morphine analgesia recorded lower pain scores at 30 min than comparable patients in the fentanyl group (P < 0.03). These findings suggest that neither drug provides sufficient analgesia for laparoscopic sterilization when given as a sole analgesic. Investigation of a combined analgesic technique employing morphine and a non-steroidal anti-inflammatory drug is warranted.
在接受腹腔镜绝育手术的患者中，比较了术前通过肌肉注射给予双氯芬酸钠作为镇痛药的麻醉技术与采用静脉注射芬太尼的麻醉技术的效果。术后疼痛明显，两种药物都仅提供了部分缓解。双氯芬酸组患者的疼痛评分最初高于芬太尼组，两组之间的差异具有统计学意义（P < 0.02）。接受术后补充吗啡镇痛的双氯芬酸组患者在30分钟时的疼痛评分低于芬太尼组中的类似患者（P < 0.03）。这些发现表明，当作为唯一的镇痛药使用时，两种药物都不能为腹腔镜绝育手术提供足够的镇痛效果。有必要研究采用吗啡和非甾体抗炎药的联合镇痛技术。
