Ahlm C, Settergren B, Gothefors L, Juto P
Department of Infectious Diseases, University of Umeå, Sweden.
Pediatr Infect Dis J. 1994 Jan;13(1):45-9. doi: 10.1097/00006454-199401000-00010.
The clinical characteristics of serologically verified nephropathia epidemica, the Scandinavian form of hemorrhagic fever with renal syndrome, were studied in Swedish children who were < 15 years of age. In 1990 to 1992, 14 cases were prospectively followed. A retrospective survey during 1984 to 1990 disclosed another 18 cases. Among the 32 cases (20 boys, 12 girls, 3 to 15 years of age; median age, 11 years), the most common symptoms were fever (100%), headache (100%), abdominal pain (93%), vomiting (91%) and back pain (76%). Laboratory findings included elevated serum creatinine concentration (19 of 28) and thrombocytopenia (7 of 22). Urinalysis showed proteinuria (31 of 31 patients) and hematuria (24 of 30). Six children had mild hemorrhagic manifestations (epistaxis, metrorrhagia, and petechiae). No severe complications occurred. The clinical symptoms of children with nephropathia epidemica seem to be similar to those found among adult nephropathia epidemica cases.
对血清学确诊的流行性肾病（肾综合征出血热的斯堪的纳维亚型）的临床特征进行了研究，研究对象为瑞典15岁以下儿童。1990年至1992年，对14例病例进行了前瞻性随访。1984年至1990年期间的一项回顾性调查又发现了18例病例。在这32例病例（20名男孩，12名女孩，年龄3至15岁；中位年龄11岁）中，最常见的症状为发热（100%）、头痛（100%）、腹痛（93%）、呕吐（91%）和背痛（76%）。实验室检查结果包括血清肌酐浓度升高（28例中的19例）和血小板减少（22例中的7例）。尿液分析显示蛋白尿（31例患者中的31例）和血尿（30例中的24例）。6名儿童有轻度出血表现（鼻出血、子宫出血和瘀点）。未发生严重并发症。流行性肾病患儿的临床症状似乎与成人流行性肾病病例中的症状相似。
