Guitton J, David O, Mialon A, Manchon M
Laboratoire des urgences biochimiques et toxicologiques, hôpital Jules-Courmont, centre hospitalier Lyon-Sud, Pierre-Bénite, France.
Ann Biol Clin (Paris). 1993;51(6):611-7.
This study evaluated an automated high performance liquid chromatography algorithm that allows identification of 330 substances and metabolites in biological fluids. We assessed its ability to detect in urine and gastric lavage fluids the main psychotropic drugs ingested with suicidal intent. Antidepressants and most of the phenothiazines were recognised; identification of benzodiazepines was more uncertain. Compared to EMIT techniques, chromatography is less sensitive, but allows precise identification of the offending poison, quantifies the amount, and allows broad toxicological screening of pharmacological classes inaccessible to the EMIT technique.
本研究评估了一种自动化高效液相色谱算法，该算法可识别生物体液中的330种物质和代谢物。我们评估了其检测尿液和洗胃液中有意摄入的主要精神药物的能力。抗抑郁药和大多数吩噻嗪类药物可被识别；苯二氮䓬类药物的识别则更不确定。与酶倍增免疫测定技术（EMIT）相比，色谱法的灵敏度较低，但能精确识别致病毒物，定量其含量，并能对EMIT技术无法检测的药理学类别进行广泛的毒理学筛查。
