人、鸡、大鼠和小鼠血小板中的苯基戊酸酯和胆碱酯水解酶

Phenyl valerate and choline ester hydrolases in the platelets of human, hen, rat and mouse.

Husain K

Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.

Hum Exp Toxicol. 1994 Mar;13(3):157-9. doi: 10.1177/096032719401300303.

Abstract

The levels of phenyl valerate and choline ester hydrolases in the platelets of human and certain laboratory animals have been determined for comparison. 2. The activities of total phenyl valerate hydrolase (PVase), paraoxon insensitive phenyl valerate hydrolase (PI-PVase), paraoxon and mipafox resistant esterase (PMRE) and propionyl-cholinesterase (PChE) were maximal in hen followed by mouse, rat and human. 3. Neurotoxic esterase (NTE) and acetylcholinesterase (AChE) activities were concentrated in the platelets of hens followed by humans, rats and mice in order. 4. Maximum concentration of butyrylcholinesterase (BChE) was found in the platelets of hens followed by mice, humans and rats. 5. It is concluded that the normal levels of enzyme activities in the platelets of humans and various species of animals may help to evaluate the exposure risk to neurotoxic organophosphorous compounds.

摘要

已测定人类和某些实验动物血小板中戊酸苯酯和胆碱酯酶的水平以作比较。2. 总戊酸苯酯水解酶（PVase）、对氧磷不敏感的戊酸苯酯水解酶（PI - PVase）、对氧磷和丙氟磷抗性酯酶（PMRE）以及丙酰胆碱酯酶（PChE）的活性在母鸡中最高，其次是小鼠、大鼠和人类。3. 神经毒性酯酶（NTE）和乙酰胆碱酯酶（AChE）的活性集中在母鸡的血小板中，其次依次是人类、大鼠和小鼠。4. 在母鸡的血小板中发现丁酰胆碱酯酶（BChE）的浓度最高，其次是小鼠、人类和大鼠。5. 得出结论，人类和各种动物血小板中酶活性的正常水平可能有助于评估神经毒性有机磷化合物的暴露风险。