el-Refaey H, Calder L, Wheatley D N, Templeton A
Department of Obstetrics and Gynaecology, University Medical School, Aberdeen, UK.
Lancet. 1994 May 14;343(8907):1207-9. doi: 10.1016/s0140-6736(94)92406-6.
Although it is well established that cervical priming before surgically induced abortion reduces the incidence of complications, its use is infrequent and confined to groups perceived to be at high risk. We compared the effect of prostaglandin E1 analogues, gemeprost and misoprostol, on the cervix. Both induced clinical and histochemical changes that were significantly different from controls and were likely to have therapeutic value. Misoprostol, however, is cheap, easily stored, and associated with few side-effects. Cervical pre-dilation with misoprostol may be considered in all women having surgically induced abortions.
虽然手术流产前进行宫颈预处理可降低并发症发生率已得到充分证实，但其应用并不常见，且仅限于被认为是高风险的人群。我们比较了前列腺素E1类似物吉美前列素和米索前列醇对宫颈的作用。两者均引起了与对照组有显著差异的临床和组织化学变化，且可能具有治疗价值。然而，米索前列醇价格便宜、易于储存且副作用少。对于所有接受手术流产的女性，均可考虑使用米索前列醇进行宫颈预扩张。
