Malinowski A, Szpakowski M, Tchórzewski H, Zeman K, Pawlowicz P, Wozniak P
Department of Obstetrics and Gynecology, Military School of Medicine, Polish Mother's Memorial Hospital, Lodz.
Eur J Obstet Gynecol Reprod Biol. 1994 Jan;53(1):27-31. doi: 10.1016/0028-2243(94)90133-3.
The purpose of this study was to assess whether any changes occur in the cellular immunity in normal and pre-eclamptic pregnancy. T lymphocyte subpopulations and the lymphocyte proliferative responses to mitogens (PHA, Con A, PWM) in the fetal calf serum were examined in normal pregnant and pre-eclamptic primiparas in the third trimester of pregnancy. In normal pregnancy the absolute and percentage numbers of CD3+ and CD4+ T cells were significantly lower and the CD4+/CD8+ ratio almost halved, in comparison with non-pregnant subjects. In the pre-eclamptic women a decreased absolute and percentage content of CD8+ T cells and increased percentage of CD3+ and CD4+ lymphocytes were found--in comparison with the normal pregnant women--which led to an almost 2.5-fold increase of the CD4+/CD8+ ratio. No disorders were found in the lymphocyte proliferative responses to mitogens in either normal or pre-eclamptic pregnancy. We conclude that despite the shifts among T lymphocyte subsets, mitogen-induced lymphocyte proliferation presents its functional stability and unchanged reactivity in normal and pre-eclamptic pregnancy.
本研究的目的是评估正常妊娠和子痫前期妊娠的细胞免疫是否发生任何变化。检测了妊娠晚期正常妊娠和子痫前期初产妇胎牛血清中的T淋巴细胞亚群以及淋巴细胞对丝裂原（PHA、Con A、PWM）的增殖反应。与未孕女性相比，正常妊娠时CD3+和CD4+ T细胞的绝对数量和百分比显著降低，CD4+/CD8+比值几乎减半。与正常妊娠女性相比，子痫前期女性CD8+ T细胞的绝对含量和百分比降低，CD3+和CD4+淋巴细胞的百分比增加，导致CD4+/CD8+比值几乎增加了2.5倍。正常妊娠和子痫前期妊娠的淋巴细胞对丝裂原的增殖反应均未发现异常。我们得出结论，尽管T淋巴细胞亚群之间发生了变化，但丝裂原诱导的淋巴细胞增殖在正常妊娠和子痫前期妊娠中表现出其功能稳定性和反应性不变。
