与人类皮肤利什曼病治愈相关的利什曼原虫反应性CD4+和CD8+ T细胞。
Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.
作者信息
Da-Cruz A M, Conceição-Silva F, Bertho A L, Coutinho S G
机构信息
Department of Protozoology, Oswaldo Cruz Institute-FIOCRUZ, Rio de Janeiro, Brazil.
出版信息
Infect Immun. 1994 Jun;62(6):2614-8. doi: 10.1128/iai.62.6.2614-2618.1994.
Abstract
Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.
摘要
对14例美洲皮肤利什曼病患者进行了研究。进行了体外由巴西利什曼原虫抗原诱导的淋巴细胞增殖反应测定。培养5天后，收获巴西利什曼原虫刺激的母细胞化T细胞用于CD4 +和CD8 +表型分析。比较治疗前和治疗结束时的结果，利什曼病患者培养物中CD8 +母细胞化T细胞百分比增加，CD4 +母细胞化T细胞比例下降。当患者治愈时，T细胞培养上清液中的γ干扰素水平呈上升趋势。这些结果显示治愈后利什曼原虫反应性CD8 + T细胞比例较高、利什曼原虫反应性CD4 + T细胞比例较低的模式。
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