与人类皮肤利什曼病治愈相关的利什曼原虫反应性CD4+和CD8+ T细胞。
Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.
作者信息
Da-Cruz A M, Conceição-Silva F, Bertho A L, Coutinho S G
机构信息
Department of Protozoology, Oswaldo Cruz Institute-FIOCRUZ, Rio de Janeiro, Brazil.
出版信息
Infect Immun. 1994 Jun;62(6):2614-8. doi: 10.1128/iai.62.6.2614-2618.1994.
Abstract
Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.
摘要
对14例美洲皮肤利什曼病患者进行了研究。进行了体外由巴西利什曼原虫抗原诱导的淋巴细胞增殖反应测定。培养5天后，收获巴西利什曼原虫刺激的母细胞化T细胞用于CD4 +和CD8 +表型分析。比较治疗前和治疗结束时的结果，利什曼病患者培养物中CD8 +母细胞化T细胞百分比增加，CD4 +母细胞化T细胞比例下降。当患者治愈时，T细胞培养上清液中的γ干扰素水平呈上升趋势。这些结果显示治愈后利什曼原虫反应性CD8 + T细胞比例较高、利什曼原虫反应性CD4 + T细胞比例较低的模式。
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本文引用的文献
1
Can soluble antigens induce CD8+ cytotoxic T-cell responses? A paradox revisited.
Immunol Today. 1993 Jul;14(7):344-8. doi: 10.1016/0167-5699(93)90233-B.
2
Recombinant vaccinia viruses expressing GP46/M-2 protect against Leishmania infection.表达GP46/M-2的重组痘苗病毒可预防利什曼原虫感染。
Infect Immun. 1993 Aug;61(8):3351-9. doi: 10.1128/iai.61.8.3351-3359.1993.
3
Induction of cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein by immunization with soluble recombinant protein without adjuvant.通过无佐剂的可溶性重组蛋白免疫诱导针对恶性疟原虫环子孢子蛋白的细胞毒性T淋巴细胞。
Infect Immun. 1993 Dec;61(12):5062-6. doi: 10.1128/iai.61.12.5062-5066.1993.
4
T cell response in murine Leishmania mexicana amazonensis infection: production of interferon-gamma by CD8+ cells.墨西哥利什曼原虫亚马逊亚种感染小鼠中的T细胞反应：CD8⁺细胞产生γ干扰素
Eur J Immunol. 1993 May;23(5):1181-4. doi: 10.1002/eji.1830230532.
5
Induction by specific T lymphocytes of intracellular destruction of Leishmania major in infected murine macrophages.感染鼠巨噬细胞中利什曼原虫主要种的细胞内破坏由特异性T淋巴细胞诱导产生。
Parasite Immunol. 1984 Mar;6(2):157-69. doi: 10.1111/j.1365-3024.1984.tb00789.x.
6
Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica.实验性皮肤利什曼病的免疫调节。III. 对热带利什曼原虫高度易感小鼠中细胞介导免疫特异性抑制的性质和意义。
J Exp Med. 1980 Sep 1;152(3):594-607. doi: 10.1084/jem.152.3.594.
7
The in vitro generation and functional analysis of murine T cell populations and clones specific for a protozoan parasite, Leishmania tropica.
Immunol Rev. 1982;61:215-43. doi: 10.1111/j.1600-065x.1982.tb00378.x.
8
Cell mediated immunity in American cutaneous and mucosal leishmaniasis.美洲皮肤和黏膜利什曼病中的细胞介导免疫
J Immunol. 1985 Dec;135(6):4144-8.
9
10
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