低浓度青霉素和磺胺嘧啶对变形链球菌的体外作用
In vitro effects of low concentrations of penicillin and sulfadiazine on Streptococcus mutans.
作者信息
Weld H G, Sandham H J
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):196-9. doi: 10.1128/AAC.10.2.196.
Investigations were conducted to determine the in vitro effects of low levels of penicillin and sulfadiazine on the growth, plaque formation, and agglutination of Streptococcus mutans and on the synthesis and activity of enzymes synthesizing extracellular polymers. The concentrations tested were equivalent to those expected in the saliva of subjects receiving oral therapy with the agents. Penicillin at 0.5 ng/ml and sulfadiazine at 1 mug/ml substantially inhibited in vitro plaque formation. At these concentrations, sulfadiazine but not penicillin also inhibited growth of the organism. Neither antimicrobial agent affected the agglutination of S. mutans with dextran or the synthesis or activity of enzymes synthesizing extracellular polymers. The effect of sulfadiazine on plaque formation was attributed, at least in part, to the inhibitory action of that agent on S. mutans growth.
开展了多项研究，以确定低水平青霉素和磺胺嘧啶对变形链球菌生长、菌斑形成、凝集作用以及合成细胞外聚合物的酶的合成与活性的体外影响。所测试的浓度与接受这些药物口服治疗的受试者唾液中预期的浓度相当。0.5纳克/毫升的青霉素和1微克/毫升的磺胺嘧啶可显著抑制体外菌斑形成。在这些浓度下，磺胺嘧啶而非青霉素也抑制了该生物体的生长。两种抗菌剂均未影响变形链球菌与葡聚糖的凝集作用，也未影响合成细胞外聚合物的酶的合成或活性。磺胺嘧啶对菌斑形成的影响至少部分归因于该药物对变形链球菌生长的抑制作用。
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