Järvinen H, Pienihäkkinen K, Huovinen P, Tenovuo J
Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.
Eur J Oral Sci. 1995 Feb;103(1):32-5. doi: 10.1111/j.1600-0722.1995.tb00007.x.
Effects of three different types of short-term applications (1-3 times during 1 week) of chlorhexidine (1 or 40%) on the susceptibility of 863 clinical isolates of Streptococcus mutans and 53 isolates of Streptococcus sobrinus from 58 subjects were studied. Chlorhexidine-resistant isolates were not found either before or after the treatment. The minimum inhibitory concentrations (MICs) to chlorhexidine of all isolates of S. mutans were < or = 1 microgram/ml, and of S. sobrinus < or = 2 micrograms/ml. S. mutans and S. sobrinus were also susceptible to ampicillin, penicillin, cefuroxime, and tetracycline. In conclusion, different short-term chlorhexidine regimens do not induce resistance in S. mutans or S. sobrinus and, furthermore, these species have so far retained their susceptibility to common antibiotics.
研究了三种不同类型的短期应用（1周内1 - 3次）洗必泰（1%或40%）对来自58名受试者的863株变形链球菌临床分离株和53株远缘链球菌分离株敏感性的影响。治疗前后均未发现洗必泰耐药菌株。所有变形链球菌分离株对洗必泰的最低抑菌浓度（MIC）≤1微克/毫升，远缘链球菌的MIC≤2微克/毫升。变形链球菌和远缘链球菌对氨苄西林、青霉素、头孢呋辛和四环素也敏感。总之，不同的短期洗必泰用药方案不会诱导变形链球菌或远缘链球菌产生耐药性，而且，到目前为止这些菌种仍对常用抗生素敏感。
