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评估β-内酰胺酶不敏感青霉素和头孢菌素在大肠杆菌菌株中渗透性的间接方法。

Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.

作者信息

Richmond M H, Clark D C, Wotton S

出版信息

Antimicrob Agents Chemother. 1976 Aug;10(2):215-8. doi: 10.1128/AAC.10.2.215.

DOI:10.1128/AAC.10.2.215
PMID:791092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429723/
Abstract

Escherichia coli UB1005 and two mutants of this strain (DC2 and DC3) have been used to assess indirectly the relative ability of various beta-lactam antibiotics to penetrate the outer layers of E. coli. Benzylpenicillin, ampicillin, methicillin, cloxacillin, cephaloridine, cephalothin, and cephalexin have been examined. The results confirm those obtained with other methods and show that, among the compounds studied here, cephalosporins seem to penetrate more readily than penicillins.

摘要

大肠杆菌UB1005及其两个突变株（DC2和DC3）已被用于间接评估各种β-内酰胺抗生素穿透大肠杆菌外层的相对能力。研究了苄青霉素、氨苄青霉素、甲氧西林、氯唑西林、头孢菌素、头孢噻吩和头孢氨苄。结果证实了用其他方法获得的结果，并表明，在此研究的化合物中，头孢菌素似乎比青霉素更容易穿透。

相似文献

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Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.评估β-内酰胺酶不敏感青霉素和头孢菌素在大肠杆菌菌株中渗透性的间接方法。
Antimicrob Agents Chemother. 1976 Aug;10(2):215-8. doi: 10.1128/AAC.10.2.215.
2
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beta-Lactamase and beta-lactam antibiotics resistance in acinetobacter anitratum (syn: A. calcoaceticus).抗硝酸不动杆菌（同义词：醋酸钙不动杆菌）中的β-内酰胺酶与β-内酰胺类抗生素耐药性
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本文引用的文献

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Site of action of radiopenicillin.放射性青霉素的作用部位。
Bacteriol Rev. 1956 Mar;20(1):28-48. doi: 10.1128/br.20.1.28-48.1956.
2
The purification and properties of a penicillinase whose synthesis is mediated by an R-factor in Escherichia coli.一种由大肠杆菌中的R因子介导合成的青霉素酶的纯化及其性质
Biochem J. 1966 Jan;98(1):204-9. doi: 10.1042/bj0980204.
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The surface localization of penicillinases in Escherichia coli and Salmonella typhimurium.青霉素酶在大肠杆菌和鼠伤寒沙门氏菌中的表面定位
Biochem Biophys Res Commun. 1968 Jul 26;32(2):258-63. doi: 10.1016/0006-291x(68)90378-1.
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Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.青霉素与细菌细胞的相互作用：青霉素结合蛋白和青霉素敏感酶。
Bacteriol Rev. 1974 Sep;38(3):291-335. doi: 10.1128/br.38.3.291-335.1974.
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The DD-carboxypeptidase-transpeptidase system in Escherichia coli mutant strain.大肠杆菌突变菌株中的DD-羧肽酶-转肽酶系统
Ann N Y Acad Sci. 1974 May 10;235(0):225-35. doi: 10.1111/j.1749-6632.1974.tb43268.x.
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Penicillin resistance in Escherichia coli K12: synergism between penicillinases and a barrier in the outer part of the envelope.大肠杆菌K12中的青霉素抗性：青霉素酶与细胞膜外层屏障之间的协同作用。
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Cefoxitin, a semisynthetic cephamycin antibiotic: resistance to beta-lactamase inactivation.头孢西丁，一种半合成头孢霉素抗生素：对β-内酰胺酶灭活的抗性。
Antimicrob Agents Chemother. 1974 Jan;5(1):38-48. doi: 10.1128/AAC.5.1.38.
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The beta-lactamases of gram-negative bacteria and their possible physiological role.革兰氏阴性菌的β-内酰胺酶及其可能的生理作用。
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The interplay of beta-lactamases and intrinsic factors in the resistance of gram-negative bacteria to penicillins and cephalosporins.β-内酰胺酶与内在因素在革兰氏阴性菌对青霉素和头孢菌素耐药性中的相互作用。
Ann N Y Acad Sci. 1974 May 10;235(0):553-68. doi: 10.1111/j.1749-6632.1974.tb43290.x.
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Binding of 14 C-penicillin G to Proteus mirabilis.
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