评估β-内酰胺酶不敏感青霉素和头孢菌素在大肠杆菌菌株中渗透性的间接方法。
Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.
作者信息
Richmond M H, Clark D C, Wotton S
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):215-8. doi: 10.1128/AAC.10.2.215.
Abstract
Escherichia coli UB1005 and two mutants of this strain (DC2 and DC3) have been used to assess indirectly the relative ability of various beta-lactam antibiotics to penetrate the outer layers of E. coli. Benzylpenicillin, ampicillin, methicillin, cloxacillin, cephaloridine, cephalothin, and cephalexin have been examined. The results confirm those obtained with other methods and show that, among the compounds studied here, cephalosporins seem to penetrate more readily than penicillins.
摘要
大肠杆菌UB1005及其两个突变株（DC2和DC3）已被用于间接评估各种β-内酰胺抗生素穿透大肠杆菌外层的相对能力。研究了苄青霉素、氨苄青霉素、甲氧西林、氯唑西林、头孢菌素、头孢噻吩和头孢氨苄。结果证实了用其他方法获得的结果，并表明，在此研究的化合物中，头孢菌素似乎比青霉素更容易穿透。
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