七种头孢菌素的比较研究：对β-内酰胺酶的敏感性及穿透大肠杆菌表层的能力
Comparative study of seven cephalosporins: susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coli.
作者信息
Richmond M H, Wotton S
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):219-22. doi: 10.1128/AAC.10.2.219.
Abstract
The properties of cefazolin, cefoxitin, cefamandole, and cefuroxime have been compared with those of cephaloridine, cephalothin, and cephalexin. The properties included for examination are the susceptibility to a range of beta-lactamases commonly encountered in gram-negative species and the ability of a beta-lactam antibiotic to penetrate the outer layers of Escherichia coli. Of the antibiotics tested, cefamandole was the most active in its antibiotic activity but had the disadvantage that it was sensitive to hydrolysis by type IVc beta-lactamase. Cefoxitin and cefuroxime were slightly less active than cefamandole but were effectively resistant to all the beta-lactamases used in the test.
摘要
已将头孢唑林、头孢西丁、头孢孟多和头孢呋辛的特性与头孢噻啶、头孢噻吩和头孢氨苄的特性进行了比较。用于检查的特性包括对革兰氏阴性菌中常见的一系列β-内酰胺酶的敏感性以及β-内酰胺抗生素穿透大肠杆菌外层的能力。在所测试的抗生素中，头孢孟多在其抗菌活性方面最为活跃，但缺点是它对IVc型β-内酰胺酶的水解敏感。头孢西丁和头孢呋辛的活性略低于头孢孟多，但对测试中使用的所有β-内酰胺酶均有效耐药。
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