产生肾素的人副神经节瘤中的多种神经肽免疫反应性
Multiple neuropeptide immunoreactivities in a renin-producing human paraganglioma.
作者信息
Fried G, Wikström L M, Höög A, Arver S, Cedermark B, Hamberger B, Grimelius L, Meister B
机构信息
Department of Obstetrics and Gynecology, Karolinska Institute, Stockholm, Sweden.
出版信息
Cancer. 1994 Jul 1;74(1):142-51. doi: 10.1002/1097-0142(19940701)74:1<142::aid-cncr2820740123>3.0.co;2-o.
BACKGROUND
A case of a renin-producing paraganglioma of adrenal origin with metastases to the retroperitoneal area, paravaginal area, and the ovary is reported with immunohistochemical findings indicating expression of multiple neuropeptide immunoreactivities. The patient was 23 years old at the time of diagnosis, and died from metastatic spread of the tumor 7 years later.
METHODS
Tumor tissue was examined by light microscopy, indirect immunohistochemistry, and electron microscopy.
RESULTS
The tumor tissue investigated contained several cells exhibiting opioid peptide-like immunoreactivities (i.e., enkephalin and dynorphin-like immunoreactivity [LI]). A lower number of cells displayed neuropeptide Y-, galanin-, somatostatin-, neurotensin-, substance P-, peptide histidine-isoleucine-, cholecystokinin-, renin-, and calbindin-LI.
CONCLUSION
To the authors' knowledge, galanin, dynorphin, peptide histidine-isoleucine, cholecystokinin, and calbindin have not been reported previously to occur in paraganglioma, and renin has been reported to occur very rarely. A review of recent literature suggest that enkephalin-, neuropeptide Y-, and somatostatin-like immunoreactivities may be useful as diagnostic markers for paragangliomas.
背景
报告一例肾上腺来源的产生肾素的副神经节瘤，发生转移至腹膜后区域、阴道旁区域和卵巢，免疫组化结果显示多种神经肽免疫反应性表达。该患者诊断时23岁，7年后死于肿瘤的转移扩散。
方法
对肿瘤组织进行光学显微镜检查、间接免疫组化和电子显微镜检查。
结果
所研究的肿瘤组织含有多个呈现阿片肽样免疫反应性（即脑啡肽和强啡肽样免疫反应性[LI]）的细胞。较少数量的细胞显示神经肽Y、甘丙肽、生长抑素、神经降压素、P物质、肽组氨酸异亮氨酸、胆囊收缩素、肾素和钙结合蛋白-LI。
结论
据作者所知，甘丙肽、强啡肽、肽组氨酸异亮氨酸、胆囊收缩素和钙结合蛋白此前尚未见在副神经节瘤中出现的报道，肾素的出现报道也极为罕见。近期文献综述表明，脑啡肽、神经肽Y和生长抑素样免疫反应性可能作为副神经节瘤的诊断标志物。
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