[Early stages of myocardial infarct studied by opitcal methods].

The hearts of 45 dogs were investigated at times from 10 minutes to 24 hours following ligation of the anterior interventricular branch of the left coronary artery. The material was fixed in formalin and embedded in parafin. It was established that at early stages of experimental myocardial infarction in the zone of eschemia there took place eschemic zone various foms of contactural damages, lumpy decmposition, relaxation and sarcoplasmic matrix. By the polarizing microscope method in the peripheral area of the eshemic zone various forms of contractural damages, lumpy decomposition, relaxation and desaggregation of myofibrills, were noted. Phaso-contrast and interference microscopy investigations revealed in the damaged cells an induration of the sarcoplasmic matrix due to an increase in the dry matter concentration. The studies conducted with the help of polarizing, phaso-contrast, and interference microscopy methods showed that by using these methods it is possible at early periods to reveal the zone of myocardial infarction on stained and unstained preparations prepared by conventional methods.