严重联合免疫缺陷（SCID）小鼠中的人类血液淋巴细胞
Human hematolymphoid cells in SCID mice.
作者信息
Kaneshima H, Namikawa R, McCune J M
机构信息
New Enterprise Research Division, SyStemix Inc, Palo Alto, California 94304.
出版信息
Curr Opin Immunol. 1994 Apr;6(2):327-33. doi: 10.1016/0952-7915(94)90109-0.
The severe combined immunodeficient C.B.-17 scid/scid (SCID) mouse has been widely used to study the normal processes of murine lymphoid differentiation. To create an in vivo model of the human hematolymphoid system, this mouse strain has been engrafted with human organ systems (the SCID-hu mouse) or with human peripheral blood mononuclear cells (the hu-PBL-SCID mouse). These mouse models have now been characterized and used to analyze human infectious diseases, hematopoiesis, malignancies and vaccines.
严重联合免疫缺陷的C.B.-17 scid/scid（SCID）小鼠已被广泛用于研究小鼠淋巴细胞分化的正常过程。为了建立人类血液淋巴系统的体内模型，该小鼠品系已植入人类器官系统（SCID-hu小鼠）或人类外周血单个核细胞（hu-PBL-SCID小鼠）。这些小鼠模型现已得到表征，并用于分析人类传染病、造血作用、恶性肿瘤和疫苗。
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