强迫症、精神分裂症、阿尔茨海默病、多发性硬化症及晚期HIV感染患者体内生长抑素-14和前强啡肽209-240的血清抗体。

Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection.

作者信息

Roy B F, Benkelfat C, Hill J L, Pierce P F, Dauphin M M, Kelly T M, Sunderland T, Weinberger D R, Breslin N

机构信息

Psychiatry Service, Veterans Affairs Medical Center, Albany, NY 12208.

出版信息

Biol Psychiatry. 1994 Mar 1;35(5):335-44. doi: 10.1016/0006-3223(94)90037-x.

DOI:10.1016/0006-3223(94)90037-x

PMID:7912113

Abstract

Patients with obsessive-compulsive disorder (OCD) demonstrated significant levels of antibody for somatostatin-28, its C-terminal fragment somatostatin-14, and prodynorphin. In contrast there were lower levels of reactivity for somatostatin-28(1-14) (the N-terminal fragment of somatostatin-28) and negligible reactivity for several other peptides including beta-endorphin and corticotropin. Healthy volunteers and disease controls [schizophrenia, Alzheimer's disease, multiple sclerosis, and subjects with advanced human immunodeficiency virus (HIV) infection] exhibited negligible reactivity. These data raise the consideration of an autoimmune mechanism for some OCD.

摘要

强迫症（OCD）患者体内生长抑素-28、其C末端片段生长抑素-14和前强啡肽的抗体水平显著升高。相比之下，生长抑素-28（1-14）（生长抑素-28的N末端片段）的反应性较低，而包括β-内啡肽和促肾上腺皮质激素在内的其他几种肽的反应性可忽略不计。健康志愿者和疾病对照组[精神分裂症、阿尔茨海默病、多发性硬化症以及晚期人类免疫缺陷病毒（HIV）感染患者]的反应性可忽略不计。这些数据引发了对某些强迫症自身免疫机制的思考。