Oikkonen M
Department of Anaesthesia, Tampere University Hospital, Finland.
Acta Anaesthesiol Scand. 1994 Apr;38(3):211-3.
Given as a peroral premedicant for geriatric patients having cataract surgery under regional block, a butyrophenone neuroleptic melperon (15-30 mg, n = 50) ranked equally with diazepam (4-10 mg, n = 50), assessed using a qualitative subjective estimation of the patients' anxiety. The patients treated with melperon needed significantly fewer supplementations with intravenous drugs, to withstand the surgery, compared to those medicated with diazepam. Melperon is a compatible alternative, but its possible propensity to cause occasional arterial hypotension must be noticed.
对于在区域阻滞下进行白内障手术的老年患者，作为口服术前用药，丁酰苯类抗精神病药美哌隆（15 - 30毫克，n = 50）与地西泮（4 - 10毫克，n = 50）效果相当，这是通过对患者焦虑程度进行定性主观评估得出的。与接受地西泮治疗的患者相比，接受美哌隆治疗的患者在手术过程中需要显著更少的静脉药物补充来耐受手术。美哌隆是一种合适的替代药物，但必须注意其偶尔可能导致动脉低血压的倾向。
