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相似文献

1
Resuspension of platelets: enhanced 5-hydroxytryptamine-induced aggregation in chlorpromazine treated patients due to changes in platelet properties.血小板再悬浮：由于血小板特性改变，氯丙嗪治疗的患者中5-羟色胺诱导的聚集增强。
Br J Clin Pharmacol. 1975 Feb;2(1):37-9. doi: 10.1111/j.1365-2125.1975.tb00469.x.
2
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.
3
Serotonin receptor site in human platelets from control and chlorpromazine treated subjects.来自对照受试者和氯丙嗪治疗受试者的人血小板中的血清素受体位点。
Prog Biochem Pharmacol. 1980;16:119-32.
4
Increased platelet aggregation in patients receiving chlorpromazine: responses to 5-hydroxytryptamine, dopamine and N-dimethyl dopamine.氯丙嗪治疗患者的血小板聚集增加：对 5-羟色胺、多巴胺和 N-二甲基多巴胺的反应。
Br J Clin Pharmacol. 1976 Aug;3(4):649-53. doi: 10.1111/j.1365-2125.1976.tb04889.x.
5
Increases in aggregation by and uptake of 5-hydroxytryptamine with platelets from rabbits treated with chlorpromazine.氯丙嗪处理的兔血小板对5-羟色胺的聚集作用及摄取增加。
Br J Pharmacol. 1980 May;69(1):113-8. doi: 10.1111/j.1476-5381.1980.tb10889.x.
6
Human platelet function as a model for investigating the clinical efficacy of chlorpromazine.人体血小板功能作为研究氯丙嗪临床疗效的模型。
Br J Clin Pharmacol. 1981 Oct;12(4):535-42. doi: 10.1111/j.1365-2125.1981.tb01262.x.
7
Effects of chlorpromazine on serotonin uptake in blood platelets.氯丙嗪对血小板中血清素摄取的影响。
Psychiatry Res. 1983 May;9(1):23-8. doi: 10.1016/0165-1781(83)90085-9.
8
Shape change and aggregation of blood platelets: interaction between the effects of adenosine and diphosphate, 5-hydroxytryptamine and adrenaline.血小板的形态变化与聚集：腺苷、二磷酸、5-羟色胺及肾上腺素作用之间的相互影响
Br J Pharmacol. 1976 Feb;56(2):209-18. doi: 10.1111/j.1476-5381.1976.tb07444.x.
9
Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
Br J Pharmacol. 1975 Jan;53(1):121-5. doi: 10.1111/j.1476-5381.1975.tb07338.x.
10
Platelet function after the administration of chlorpromazine to human subjects.给人类受试者服用氯丙嗪后的血小板功能。
Haemostasis. 1976;5(1):21-6. doi: 10.1159/000214115.

引用本文的文献

1
Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41,468), a selective 5-HT2-receptor antagonist. 1982.酮色林（R 41,468），一种选择性5-HT2受体拮抗剂，对5-羟色胺诱导和增强的人血小板聚集的抑制作用。1982年。
Agents Actions. 1994 Dec;43(3-4):225-34. doi: 10.1007/BF01986694.
2
Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist.酮色林（R 41 468），一种选择性5-HT2受体拮抗剂，对5-羟色胺诱导和增强的人血小板聚集的抑制作用。
Agents Actions. 1982 Jul;12(3):388-97. doi: 10.1007/BF01965409.
3
Platelet shape change in patients with psychiatric disorders and treated with phenothiazines, thioxanthines, butyrophenones, benzodiazepines, tricyclic antidepressants and beta-adrenergic blocking agents.患有精神疾病并接受吩噻嗪类、硫杂蒽类、丁酰苯类、苯二氮䓬类、三环类抗抑郁药和β-肾上腺素能阻滞剂治疗的患者的血小板形状变化。
J Neural Transm. 1981;51(3-4):245-56. doi: 10.1007/BF01248956.
4
The reliability of 5-hydroxytryptamine induced platelet aggregation responses in schizophrenic patients treated with neuroleptic drugs.使用抗精神病药物治疗的精神分裂症患者中5-羟色胺诱导的血小板聚集反应的可靠性。
Br J Clin Pharmacol. 1981 Mar;11(3):261-3. doi: 10.1111/j.1365-2125.1981.tb00531.x.
5
Assessment of anti-psychotic drugs.抗精神病药物的评估。
Br J Clin Pharmacol. 1981 Mar;11(3):225-36. doi: 10.1111/j.1365-2125.1981.tb00526.x.

本文引用的文献

1
The action of extracellular cations on the release of the sympathetic transmitter from peripheral nerves.细胞外阳离子对周围神经交感递质释放的作用。
J Physiol. 1967 Mar;189(1):85-99. doi: 10.1113/jphysiol.1967.sp008156.
2
5-Hydroxytryptamine uptake and release in relation to aggregation of rabbit platelets.5-羟色胺摄取与释放与兔血小板聚集的关系
J Physiol. 1969 Apr;201(2):409-23. doi: 10.1113/jphysiol.1969.sp008763.
3
The relation between the 5-hydroxytryptamine content and aggregation of rabbit platelets.兔血小板中5-羟色胺含量与聚集之间的关系。
J Physiol. 1969 Apr;201(2):397-408. doi: 10.1113/jphysiol.1969.sp008762.
4
Technical methods. A simple method for the isolation of blood platelets.技术方法。一种分离血小板的简单方法。
J Clin Pathol. 1973 Aug;26(8):635-7. doi: 10.1136/jcp.26.8.635.
5
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.

血小板再悬浮：由于血小板特性改变，氯丙嗪治疗的患者中5-羟色胺诱导的聚集增强。

Resuspension of platelets: enhanced 5-hydroxytryptamine-induced aggregation in chlorpromazine treated patients due to changes in platelet properties.

作者信息

Boullin D J, Grahame-Smith D G, Grimes R P, Woods H F

出版信息

Br J Clin Pharmacol. 1975 Feb;2(1):37-9. doi: 10.1111/j.1365-2125.1975.tb00469.x.

DOI:10.1111/j.1365-2125.1975.tb00469.x
PMID:791317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1402505/
Abstract

1 Previous work showed that platelets from patients receiving chlorpromazine (CPZ) have an enhanced aggregation response to 5-HT. This was caused by an action of CPZ on the platelets, a factor borne by the plasma, or both. 2 Therefore we studied 5-HT induced aggregation of platelets from CPZ treated patients resuspended in normal plasma and from normal subjects resuspended in CPZ plasma. 3 Aggregation responses of normal platelets to 5-HT were not enhanced by resuspension either in normal plasma or in CPZ plasma. In addition the enhanced responses of platelets from CPZ treated patients did not revert to normal after resuspension in normal plasma. 4 It is concluded that the enhanced aggregation response to 5-HT seen after CPZ treatment is due to a change in the properties of the platelets rather than a factor in the plasma.

摘要
  1. 先前的研究表明，接受氯丙嗪（CPZ）治疗的患者的血小板对5-羟色胺（5-HT）的聚集反应增强。这是由CPZ对血小板的作用、血浆中携带的一种因子，或两者共同作用引起的。2. 因此，我们研究了5-HT诱导的悬浮于正常血浆中的CPZ治疗患者的血小板以及悬浮于CPZ血浆中的正常受试者的血小板的聚集情况。3. 正常血小板对5-HT的聚集反应，无论是悬浮于正常血浆还是CPZ血浆中，均未增强。此外，CPZ治疗患者的血小板的增强反应在悬浮于正常血浆后并未恢复正常。4. 得出的结论是，CPZ治疗后观察到的对5-HT的聚集反应增强是由于血小板特性的改变，而非血浆中的一种因子所致。