血小板再悬浮：由于血小板特性改变，氯丙嗪治疗的患者中5-羟色胺诱导的聚集增强。
Resuspension of platelets: enhanced 5-hydroxytryptamine-induced aggregation in chlorpromazine treated patients due to changes in platelet properties.
作者信息
Boullin D J, Grahame-Smith D G, Grimes R P, Woods H F
出版信息
Br J Clin Pharmacol. 1975 Feb;2(1):37-9. doi: 10.1111/j.1365-2125.1975.tb00469.x.
Abstract
1 Previous work showed that platelets from patients receiving chlorpromazine (CPZ) have an enhanced aggregation response to 5-HT. This was caused by an action of CPZ on the platelets, a factor borne by the plasma, or both. 2 Therefore we studied 5-HT induced aggregation of platelets from CPZ treated patients resuspended in normal plasma and from normal subjects resuspended in CPZ plasma. 3 Aggregation responses of normal platelets to 5-HT were not enhanced by resuspension either in normal plasma or in CPZ plasma. In addition the enhanced responses of platelets from CPZ treated patients did not revert to normal after resuspension in normal plasma. 4 It is concluded that the enhanced aggregation response to 5-HT seen after CPZ treatment is due to a change in the properties of the platelets rather than a factor in the plasma.
摘要
- 先前的研究表明，接受氯丙嗪（CPZ）治疗的患者的血小板对5-羟色胺（5-HT）的聚集反应增强。这是由CPZ对血小板的作用、血浆中携带的一种因子，或两者共同作用引起的。2. 因此，我们研究了5-HT诱导的悬浮于正常血浆中的CPZ治疗患者的血小板以及悬浮于CPZ血浆中的正常受试者的血小板的聚集情况。3. 正常血小板对5-HT的聚集反应，无论是悬浮于正常血浆还是CPZ血浆中，均未增强。此外，CPZ治疗患者的血小板的增强反应在悬浮于正常血浆后并未恢复正常。4. 得出的结论是，CPZ治疗后观察到的对5-HT的聚集反应增强是由于血小板特性的改变，而非血浆中的一种因子所致。
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Resuspension of platelets: enhanced 5-hydroxytryptamine-induced aggregation in chlorpromazine treated patients due to changes in platelet properties.血小板再悬浮：由于血小板特性改变，氯丙嗪治疗的患者中5-羟色胺诱导的聚集增强。
Br J Clin Pharmacol. 1975 Feb;2(1):37-9. doi: 10.1111/j.1365-2125.1975.tb00469.x.
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Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.
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